Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology

Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology

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The contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored.Recently, several epigenetic drugs developed for cancer treatment have been described to mediate therapeutic effects through the reactivation of the pomyslnaszycie.com expression of transposable elements in cancer cells.This event activates innate immunity-related pathways and promotes the generation of neoantigens in tumor cells, improving the efficacy of immunotherapeutic treatments.This review focuses on the regulation of transposable elements iphone xr price calgary by epigenetic inhibitors and its implications for immuno-oncology.